Not so long ago DDR2 replaced the DDR, which in turn replaced the SDRAM from the market. Now DDR3 is a threat to DDR2, which is slowly but surely finding its stake in the market. The move towards DDR3 is mainly a step towards Green IT. DDR3 promŽises to reduce power consumption by nearly 30% as compared to DDR2.
It also offers higher bandwidth compared to DDR2, hence power users and gamers will go for DDR3. You will not find support for DDR3 in entry-level motherboards, it is mainly available in the high-end versions. For entry-level DDR2 is good enough.
It is always important to check how many DIMM slots are there in your motherboard. This could be a restricting factor in terms of expand ability. Go for boards having at least 2 D IMM slots; they will provide you an economical expandability option. Usually 4 DIMM slots are common across medium and high end motherboards, which enables them to have more expand ability options in terms of total RAM.