According to the technical support Microsoft, the error message "Windows system32 configuration of the system" can have many meanings. There is not only one computer, a problem with this might imply, but many.

Registry

One of the reasons is the registry file for your hard drive is totally missing or has become corrupted by a virus.

Attacker

One more reason is an attacker has accessed your PC by remote access and changed registry or System Root files. This means they may be copying your files and transferring them to their computer.

System Hive

One more reason is your system hive cannot be above 10.3 MB. If it increases this limit, it will prevent your PC from rebooting.

Older Versions

If you have installed an older version of Windows OS, that is considered an x64 version and your computer does not have the memory to support it.

Physical Memory

One more reason is you have exceeded the physical memory contained in the computer and it is crashing. If this is the case, connect an external hard drive instantly.